BDBM344699 US9783527, Example 2::tert-butyl 3-[1-(2-fluorophenyl)-1H-indazol-4-yl]-2-oxoimidazolidine-1-carboxylate

SMILES CC(C)(C)OC(=O)N1CCN(C1=O)c1cccc2n(ncc12)-c1ccccc1F

InChI Key InChIKey=WGXUOYQUTHHSEZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 344699   

LigandPNGBDBM344699(tert-butyl 3-[1-(2-fluorophenyl)-1H-indazol-4-yl]-...)
Affinity DataIC50: 730nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344699(tert-butyl 3-[1-(2-fluorophenyl)-1H-indazol-4-yl]-...)
Affinity DataIC50: 733nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.7 were quickly thawed and plated at 25,000 cells/well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

LigandPNGBDBM344699(tert-butyl 3-[1-(2-fluorophenyl)-1H-indazol-4-yl]-...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by Qpatch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344699(tert-butyl 3-[1-(2-fluorophenyl)-1H-indazol-4-yl]-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed