BDBM344718 1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(pyridin-4-yl)imidazolidin-2-one::US9783527, Example 20

SMILES Fc1ccccc1-n1ncc2c(cccc12)N1CCN(C1=O)c1ccncc1

InChI Key InChIKey=RPGAGCSEOOCHRH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 344718   

LigandPNGBDBM344718(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(pyridin-...)
Affinity DataIC50: 330nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by Qpatch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344718(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(pyridin-...)
Affinity DataIC50: 1.49E+3nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.7 were quickly thawed and plated at 25,000 cells/well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

LigandPNGBDBM344718(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(pyridin-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344718(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(pyridin-...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed