BDBM345162 N1,N4-bis((S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-3- (((R)-1-(2-fluorophenyl)ethyl)carbamoyl)- 1,2,3,4-tetrahydroisoquinolin-7- yl)terephthalamide::US9783573, Example 12

SMILES CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)c3ccc(cc3)C(=O)Nc3ccc4C[C@H](N(Cc4c3)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC(C)c3ccccc3F)ccc2C[C@H]1C(=O)NC(C)c1ccccc1F)C(C)(C)C

InChI Key InChIKey=HCIJWALQGPLBEB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 345162   

LigandChemical structure of BindingDB Monomer ID 345162BDBM345162(N1,N4-bis((S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methy...)
Affinity DataIC50: 130nMAssay Description:Assays were performed in black, flat-bottom, 384-well plates. The final assay volume was 50 μL prepared from additions of N-His-Tb-BIR3 (241-356...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 345162BDBM345162(N1,N4-bis((S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methy...)
Affinity DataIC50: 2.00E+3nMAssay Description:Assays were performed in white, flat-bottom, 384-well ProxiPlates (Perkin Elmer). The final assay volume was 10 μL prepared from additions of Hi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent