BDBM347791 US9790220, Example 24

SMILES Fc1ccc2nc(N[C@H]3CCC[C@@H]3NC(=O)c3ncccc3-n3ccnn3)sc2c1

InChI Key InChIKey=ZGCIMHAIPBFOLG-KBPBESRZSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 347791   

TargetOrexin receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM347791(US9790220, Example 24)
Affinity DataIC50: >1.00E+4nMAssay Description:Orexin antagonist activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM347791(US9790220, Example 24)
Affinity DataIC50:  86nMAssay Description:Orexin antagonist activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent