BDBM349050 N-(5-(4-(4,4- difluoropiperidine-1- carbonyl(phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 168

SMILES FC1(F)CCN(CC1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12

InChI Key InChIKey=UVEOCFIRZHIOLL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 349050   

TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Galapagos

US Patent
LigandPNGBDBM349050(N-(5-(4-(4,4- difluoropiperidine-1- carbonyl(pheny...)
Affinity DataIC50: 100nMAssay Description:Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM349050(N-(5-(4-(4,4- difluoropiperidine-1- carbonyl(pheny...)
Affinity DataIC50: 393nMAssay Description:Inhibition of JAK1 (unknown origin) in presence of ATP at Km concentration by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM349050(N-(5-(4-(4,4- difluoropiperidine-1- carbonyl(pheny...)
Affinity DataIC50: 401nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of ATP at Km concentration by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM349050(N-(5-(4-(4,4- difluoropiperidine-1- carbonyl(pheny...)
Affinity DataIC50: 923nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of ATP at Km concentration by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed