BDBM349193 Cyclopropanecarboxylic acid {5-[4-(3-cyano-azetidine-1- carbonyl)-phenyl]- [1,2,4]triazolo[1,5-a]pyridin-2- yl)-amide::US10206907, Compound 328

SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CC(C3)C#N)n2n1)C1CC1

InChI Key InChIKey=ZJIPUHBJFPJUGH-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 349193   

TargetTyrosine-protein kinase JAK1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM349193(Cyclopropanecarboxylic acid {5-[4-(3-cyano-azetidi...)
Affinity DataIC50: 61nMAssay Description:Inhibition of JAK1 (unknown origin) in presence of ATP at Km concentration by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM349193(Cyclopropanecarboxylic acid {5-[4-(3-cyano-azetidi...)
Affinity DataIC50: 79nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of ATP at Km concentration by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Galapagos

US Patent
LigandPNGBDBM349193(Cyclopropanecarboxylic acid {5-[4-(3-cyano-azetidi...)
Affinity DataIC50: 100nMAssay Description:Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Galapagos

US Patent
LigandPNGBDBM349193(Cyclopropanecarboxylic acid {5-[4-(3-cyano-azetidi...)
Affinity DataIC50: 100nMAssay Description:Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Galapagos

US Patent
LigandPNGBDBM349193(Cyclopropanecarboxylic acid {5-[4-(3-cyano-azetidi...)
Affinity DataIC50: 100nMAssay Description:Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM349193(Cyclopropanecarboxylic acid {5-[4-(3-cyano-azetidi...)
Affinity DataIC50: 659nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of ATP at Km concentration by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM349193(Cyclopropanecarboxylic acid {5-[4-(3-cyano-azetidi...)
Affinity DataIC50: 2.59E+3nMAssay Description:Inhibition of JAK1 (unknown origin) expressed in mouse BAF3 cells assessed as antiproliferative activity by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM349193(Cyclopropanecarboxylic acid {5-[4-(3-cyano-azetidi...)
Affinity DataIC50: 7.43E+3nMAssay Description:Inhibition of JAK2 (unknown origin) expressed in mouse BAF3 cells assessed as antiproliferative activity by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM349193(Cyclopropanecarboxylic acid {5-[4-(3-cyano-azetidi...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK3 (unknown origin) expressed in mouse BAF3 cells assessed as antiproliferative activity by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed