BDBM349219 (4R)-4-methyl-6-(1,3,3-::US10206931, Example 26

SMILES C[C@@H]1CC(=O)Nc2cccc(-c3ccc4c(c3)N(C)C(=O)C4(C)C)c2N1

InChI Key InChIKey=LJDSPXOOAXKIJZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349219   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349219BDBM349219((4R)-4-methyl-6-(1,3,3- | US10206931, Example 26)
Affinity DataIC50: 560nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349219BDBM349219((4R)-4-methyl-6-(1,3,3- | US10206931, Example 26)
Affinity DataIC50: 1.45E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent