BDBM349235 (4R)-4-methyl-6-[1-(2-pyridyl)pyrazol-4-yl]-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one::US10206931, Example 42

SMILES C[C@@H]1CC(=O)Nc2cccc(\C(C=N)=C\Nc3ccccn3)c2N1

InChI Key InChIKey=FBMBROMRVGJICZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349235   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349235BDBM349235((4R)-4-methyl-6-[1-(2-pyridyl)pyrazol-4-yl]-1,3,4,...)
Affinity DataIC50: 235nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349235BDBM349235((4R)-4-methyl-6-[1-(2-pyridyl)pyrazol-4-yl]-1,3,4,...)
Affinity DataIC50: 2.67E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent