BDBM349244 4-[(E)-2-fluoro-1-::US10206931, Example 51

SMILES C[C@@H]1CC(=O)Nc2cccc(\C(F)=C(\C)c3ccc(cc3)C#N)c2N1

InChI Key InChIKey=RYLYUTXKTYSUMQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349244   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349244BDBM349244(4-[(E)-2-fluoro-1- | US10206931, Example 51)
Affinity DataIC50: 1.03E+3nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349244BDBM349244(4-[(E)-2-fluoro-1- | US10206931, Example 51)
Affinity DataIC50: 1.66E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent