BDBM349246 (4R)-6-(1-benzyl-5-methyl-pyrazol-3-yl)-4-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one::US10206931, Example 53

SMILES C[C@@H]1CC(=O)Nc2cccc(C(=N)\C=C(\C)NCc3ccccc3)c2N1

InChI Key InChIKey=YYTABIIKEPXYPU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349246   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349246BDBM349246((4R)-6-(1-benzyl-5-methyl-pyrazol-3-yl)-4-methyl-1...)
Affinity DataIC50: 588nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349246BDBM349246((4R)-6-(1-benzyl-5-methyl-pyrazol-3-yl)-4-methyl-1...)
Affinity DataIC50: 1.08E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent