BDBM349248 (4R)-4-methyl-6-(1-methyl-3-propyl-indol-2-yl)-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one::US10206931, Example 55

SMILES CCCc1c(-c2cccc3c2N[C@H](C)CC(=O)N3)n(C)c2ccccc12

InChI Key InChIKey=ZVVXYZBNCGUJGW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349248   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349248BDBM349248((4R)-4-methyl-6-(1-methyl-3-propyl-indol-2-yl)-1,3...)
Affinity DataIC50: 851nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349248BDBM349248((4R)-4-methyl-6-(1-methyl-3-propyl-indol-2-yl)-1,3...)
Affinity DataIC50: 1.05E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent