BDBM349249 (4R)-6-(1-tert-butyl-3-methyl-indol-2-yl)-4-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one::US10206931, Example 56

SMILES C[C@@H]1CC(=O)Nc2cccc(-c3c(C)c4ccccc4n3C(C)(C)C)c2N1

InChI Key InChIKey=IQDDINKYXBDMEA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349249   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM349249((4R)-6-(1-tert-butyl-3-methyl-indol-2-yl)-4-methyl...)
Affinity DataIC50: 37nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM349249((4R)-6-(1-tert-butyl-3-methyl-indol-2-yl)-4-methyl...)
Affinity DataIC50: 898nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent