BDBM349282 (2R)-9-(3-cyclopropyl-1-methyl-Indazol-5-yl)-2-methyl-1,2,3,5-tetrahydropyrido[3,4-b][1,4]diazepin-4-one::US10206931, Example 89

SMILES CNc1ccc(cc1C(=N)C1CC1)-c1cncc2NC(=O)C[C@@H](C)Nc12

InChI Key InChIKey=MJOVPJZOZORYER-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349282   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349282BDBM349282((2R)-9-(3-cyclopropyl-1-methyl-Indazol-5-yl)-2-met...)
Affinity DataIC50: 118nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349282BDBM349282((2R)-9-(3-cyclopropyl-1-methyl-Indazol-5-yl)-2-met...)
Affinity DataIC50: 1.97E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent