BDBM349304 (2R)-2-methyl-8[(1S)-1-phenylethoxy]-3,5-dihydro-2H-1,5-benzoxazepin-4-one::US10206931, Example 111

SMILES C[C@H](Oc1ccc2NC(=O)C[C@@H](C)Oc2c1)c1ccccc1

InChI Key InChIKey=PLRQHMFRIHVCMH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349304   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349304BDBM349304((2R)-2-methyl-8[(1S)-1-phenylethoxy]-3,5-dihydro-2...)
Affinity DataIC50: 394nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349304BDBM349304((2R)-2-methyl-8[(1S)-1-phenylethoxy]-3,5-dihydro-2...)
Affinity DataIC50: 2.22E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent