BDBM349326 (4R)-4-methyl-6-(2-phenylethynyl)-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one::US10206931, Example 134

SMILES C[C@@H]1CC(=O)Nc2cccc(C#Cc3ccccc3)c2N1

InChI Key InChIKey=UQAUAUDNUGFKKO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349326   

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349326BDBM349326((4R)-4-methyl-6-(2-phenylethynyl)-1,3,4,5-tetrahyd...)
Affinity DataIC50: 1.05E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349326BDBM349326((4R)-4-methyl-6-(2-phenylethynyl)-1,3,4,5-tetrahyd...)
Affinity DataIC50: 1.97E+4nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent