BDBM349337 (2R)-2-methyl-9-(3-methyl-::US10206931, Example 145

SMILES Cc1c(-c2cccc3c2O[C@H](C)CC(=O)N3)[nH]c2ccccc12

InChI Key InChIKey=KGMUMINOQRYCMP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349337   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349337BDBM349337((2R)-2-methyl-9-(3-methyl- | US10206931, Example 1...)
Affinity DataIC50: 493nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349337BDBM349337((2R)-2-methyl-9-(3-methyl- | US10206931, Example 1...)
Affinity DataIC50: 6.58E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent