BDBM349420 (R) N-(1,1′-dimethyl-1H,1′H-[4,4′-bipyrazol]-3-yl)-4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-6-carboxamide::US10206931, Example 228

SMILES C[C@@H]1CC(=O)Nc2cccc(C(=O)Nc3nn(C)cc3-c3cnn(C)c3)c2N1

InChI Key InChIKey=QPAKLBKBJPGEQO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349420   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349420BDBM349420((R) N-(1,1′-dimethyl-1H,1′H-[4,4′...)
Affinity DataIC50: 126nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349420BDBM349420((R) N-(1,1′-dimethyl-1H,1′H-[4,4′...)
Affinity DataIC50: 6.71E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent