BDBM349421 (R)-6-(4-isopropylphenyl)-4-methyl-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one::US10206931, Example 229

SMILES CC(C)c1ccc(cc1)-c1cccc2NC(=O)C[C@@H](C)Nc12

InChI Key InChIKey=HYFIUDHDPSSCBF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349421   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349421BDBM349421((R)-6-(4-isopropylphenyl)-4-methyl-4,5-dihydro-1H-...)
Affinity DataIC50: 487nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349421BDBM349421((R)-6-(4-isopropylphenyl)-4-methyl-4,5-dihydro-1H-...)
Affinity DataIC50: 1.34E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent