BDBM349460 (4R)-4-methyl-6-[3-::US10206931, Example 268

SMILES C[C@@H]1CC(=O)Nc2cccc(-c3cnc4n(COCC[Si](C)(C)C)cnc4c3)c2N1

InChI Key InChIKey=YRGNLFAIFPXFJB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349460   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349460BDBM349460((4R)-4-methyl-6-[3- | US10206931, Example 268)
Affinity DataIC50: 317nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349460BDBM349460((4R)-4-methyl-6-[3- | US10206931, Example 268)
Affinity DataIC50: 3.38E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent