BDBM349487 US10206931, Example 295::methylpyrazol-4-yl)-

SMILES CN\C=C(/C=N)c1ccc2CCCN(c3cccc4NC(=O)C[C@@H](C)Nc34)c2c1

InChI Key InChIKey=FVJJZIQKNRXJHG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349487   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349487BDBM349487(methylpyrazol-4-yl)- | US10206931, Example 295)
Affinity DataIC50: 142nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349487BDBM349487(methylpyrazol-4-yl)- | US10206931, Example 295)
Affinity DataIC50: 1.43E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent