BDBM349684 2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-3-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid::US10208019, Example 2A-01

SMILES Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(nc12)C(O)=O

InChI Key InChIKey=ZFDHZDONBOMVLZ-UHFFFAOYSA-N

Data  1 IC50  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 349684   

TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM349684(2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...)
Affinity DataEC50:  90nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM349684(2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...)
Affinity DataEC50:  1.80E+3nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM349684(2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...)
Affinity DataEC50:  6.70nMAssay Description:Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as cAMP accumulation incubated for 30 mins in presence of BETP by BETP sensitized...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM349684(2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of hERG ion channel by patch-clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM349684(2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...)
Affinity DataEC50:  2.10E+3nMAssay Description:Agonist activity at GLP-1R (unknown origin) expressed in candidate selection CHO cells assessed as cAMP accumulation incubated for 30 mins by plate r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM349684(2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...)
Affinity DataEC50:  2.80E+3nMAssay Description:Agonist activity at human GLP-1R expressed in PathHunter CHO-K1 GLP1R beta-arrestin-2 cell assessed as induction of beta-arrestin 2 recruitment incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM349684(2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human GLP-1R expressed in PathHunter CHO-K1 GLP1R beta-arrestin-2 cells assessed as induction of beta-arrestin 2 recruitment incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM349684(2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...)
Affinity DataEC50:  95nMAssay Description:Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as cAMP accumulation incubated for 30 mins in absence of BETP by plate reader met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed