BDBM349945 (S)-5-(4-(2-(4-chlorobenzyl)-4-tosylpiperazin-1-yl)piperidin-1-yl)-4H-1,2,4-triazol-3-amine ::US10208020, Example 35

SMILES Cc1ccc(S(=O)(=O)N2CCN(C3CCN(c4nnc(N)[nH]4)CC3)[C@@H](Cc3ccc(Cl)cc3)C2)cc1

InChI Key InChIKey=ITYGAEYUQFYSGD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349945   

TargetAcidic mammalian chitinase(Human)
Oncoarendi Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 349945BDBM349945((S)-5-(4-(2-(4-chlorobenzyl)-4-tosylpiperazin-1-yl...)
Affinity DataIC50: 5.50E+3nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetChitotriosidase-1(Human)
Oncoarendi Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 349945BDBM349945((S)-5-(4-(2-(4-chlorobenzyl)-4-tosylpiperazin-1-yl...)
Affinity DataIC50: 5.50E+4nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent