BDBM352936 N-(4-Hydroxyphenyl)-N-methyl-3-{6-[(3S)-3-(morpholin-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]-2-propanoyl-2,3-dihydro-1H-isoindol-5-yl}-5,6,7,8-tetrahydroindolizine-1-carboxamide hydrochloride::US9809574, Example 11

SMILES CCC(=O)N1Cc2cc(C(=O)N3Cc4ccccc4C[C@H]3CN3CCOCC3)c(cc2C1)-c1cc(C(=O)N(C)c2ccc(O)cc2)c2CCCCn12

InChI Key InChIKey=MQRVYPJRTKUDEH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 352936   

TargetApoptosis regulator Bcl-2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 352936BDBM352936(US9809574, Example 11 | N-(4-Hydroxyphenyl)-N-meth...)
Affinity DataIC50: 22nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details
US Patent