BDBM35325 aminoquinazoline, 19

SMILES CNc1ncc2cc(ccc2n1)-c1c(C)ccc2c(Nc3cc(nn3C)C(C)(C)C)nccc12

InChI Key InChIKey=MRKUZTPMEBRBGD-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 35325   

TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM35325(aminoquinazoline, 19)
Affinity DataIC50: 21nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35325(aminoquinazoline, 19)
Affinity DataIC50: 70nM EC50:  22nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35325(aminoquinazoline, 19)
Affinity DataIC50: 110nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM35325(aminoquinazoline, 19)
Affinity DataIC50: 200nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35325(aminoquinazoline, 19)
Affinity DataIC50: 230nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed