BDBM354335 2-((2-ethyl-6-(4-(2- (3-hydroxyazetidin- 1-yl)-2- oxoethyl)piperazin- 1-yl)imidazo[1,2- a]pyrazin-3- yl)(methyl)amino)- 4-(4- fluorophenyl) thiazole-5- carbonitrile::US9796719, Compound 2

SMILES CCc1nc2cnc(cn2c1N(C)c1nc(c(s1)C#N)-c1ccc(F)cc1)N1CCN(CC(=O)N2CC(O)C2)CC1

InChI Key InChIKey=QRRUOUGSMGFUEU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354335   

TargetAutotaxin(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM354335(2-((2-ethyl-6-(4-(2- (3-hydroxyazetidin- 1-yl)-2- ...)
Affinity DataIC50: 102nMAssay Description:Inhibition of human ATX using LPC (16:0) as substrate after 30 mins by horseradish peroxidase/choline oxidase coupled enzyme based spectrophotometric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2020
Entry Details Article
PubMed
TargetAutotaxin(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM354335(2-((2-ethyl-6-(4-(2- (3-hydroxyazetidin- 1-yl)-2- ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compound IC50 values are determined in a fluorescent hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using the fluorogenic autotax...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2019
Entry Details
US Patent