BDBM354558 4-Cyano-2-methoxyphenyl 6-{1-[(4-hydroxyphenyl)(methyl)carbamoyl]-5,6,7,8-tetrahydroindolizin-3-yl}-7-[(3S)-3-(morpholin-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]-1,2,3,4-tetrahydroisoquinoline-2-carboxylate::US9809574, Example 148

SMILES COc1cc(ccc1OC(=O)N1CCc2cc(-c3cc(C(=O)N(C)c4ccc(O)cc4)c4CCCCn34)c(cc2C1)C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1)C#N

InChI Key InChIKey=IMHQDAPGPUOHKF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 354558   

TargetApoptosis regulator Bcl-2(Human)
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US Patent
LigandPNGBDBM354558(US9809574, Example 148 | 4-Cyano-2-methoxyphenyl 6...)
Affinity DataIC50: 3nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
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Date in BDB:
10/7/2019
Entry Details
US Patent