BDBM354653 Tolyl 6-[4-[(5-cyano-1,2-dimethyl-1H-pyrrol-3-yl)-(4-hydroxyphenyl)carbamoyl]-1,5-dimethyl-1H-pyrrol-2-yl]-7-[(3S)-3-(morpholinomethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]-3,4-dihydro-1H-isoquinoline-2-carboxylate hydrochloride::US9809574, Example 805

SMILES Cc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2cc3CCN(Cc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)C(=O)Oc2ccc(C)cc2)n(C)c1C)c1ccc(O)cc1

InChI Key InChIKey=DSZRTHQDDCTPPX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 354653   

TargetApoptosis regulator Bcl-2(Human)
Les Laboratoires Servier

US Patent
LigandPNGBDBM354653(US9809574, Example 805 | Tolyl 6-[4-[(5-cyano-1,2-...)
Affinity DataIC50: 3.10nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details
US Patent