BDBM355344 2-cyclopropyl-N-[(1R)-1-(4- cyclopropyl-3-fluorophenyl)-2,2- dimethylpropyl]-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US9815796, Example 435

SMILES CC(C)(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)C1CC1)c1ccc(C2CC2)c(F)c1

InChI Key InChIKey=UZBZZOSTQSJBGV-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355344   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355344(US9815796, Example 435 | 2-cyclopropyl-N-[(1R)-1-(...)
Affinity DataKi:  0.780nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355344(US9815796, Example 435 | 2-cyclopropyl-N-[(1R)-1-(...)
Affinity DataKi:  1.10nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent