BDBM355646 (1R,3S,5R)-2-[2-(3-Acetyl-5,6- dimethoxy-indazol-1-yl)- acetyl]-2-aza-bicyclo[3.1.0] hexane-3-carboxylic acid ((1R,2S)-2-phenyl- cyclopropyl)-amide::US9815819, 11

SMILES COc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3C[C@H]3c3ccccc3)c2cc1OC)C(C)=O

InChI Key InChIKey=GVWDBPAOIXLRBN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 355646   

TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM355646(US9815819, 11 | (1R,3S,5R)-2-[2-(3-Acetyl-5,6- dim...)
Affinity DataIC50: 226nMAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent