BDBM355685 1-(2-{(1R,3S,5R)-3-[2-Fluoro-2-(2- fluoro-phenyl)- cyclopropylcarbamoyl]-2-aza- bicyclo[3.1.0]hex-2-yl}-2-oxo-ethyl)- 1H-indazole-3-carboxylic acid amideDia 1::US9815819, 50::US9815819, 51::US9815819, 52::US9815819, 53

SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC2(F)c2ccccc2F)c2ccccc12

InChI Key InChIKey=OSOOTYFTZSZVJQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 355685   

TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM355685(US9815819, 50 | US9815819, 52 | US9815819, 53 | 1-...)
Affinity DataIC50: 36nMAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM355685(US9815819, 50 | US9815819, 52 | US9815819, 53 | 1-...)
Affinity DataIC50: 367nMAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM355685(US9815819, 50 | US9815819, 52 | US9815819, 53 | 1-...)
Affinity DataIC50: 992nMAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM355685(US9815819, 50 | US9815819, 52 | US9815819, 53 | 1-...)
Affinity DataIC50: 3.88E+3nMAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent