BDBM355709 1-(2-{(1R,3S,5R)-3-[2-(2,4- Difluoro-phenyl)- cyclopropylcarbamoyl]-2-aza- bicyclo[3.1.0]hex-2-yl}-2-oxo- ethyl)-1H-indazole-3-carboxylic acid amideDia 1::US9815819, 74::US9815819, 75::US9815819, 76::US9815819, 77

SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC2c2ccc(F)cc2F)c2ccccc12

InChI Key InChIKey=LFWWHVWFUBRYKQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 355709   

TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM355709(US9815819, 74 | US9815819, 75 | US9815819, 76 | US...)
Affinity DataIC50: 36nMAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM355709(US9815819, 74 | US9815819, 75 | US9815819, 76 | US...)
Affinity DataIC50: 640nMAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM355709(US9815819, 74 | US9815819, 75 | US9815819, 76 | US...)
Affinity DataIC50: 3.76E+3nMAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM355709(US9815819, 74 | US9815819, 75 | US9815819, 76 | US...)
Affinity DataIC50: 7.76E+3nMAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent