BDBM35578 pyrazolo pyrimidine, 10
SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4cccnc4)CC3)c2n1
InChI Key InChIKey=YWWSGKYAMVMIMB-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 35578
Affinity DataIC50: 0.380nMpH: 7.4 T: 23°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Wyeth Research
Wyeth Research
Affinity DataIC50: 41nMT: 25°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
Affinity DataIC50: 0.380nMAssay Description:Inhibition of Flag-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of PI3Kalpha by DELFIA assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 141nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair