BDBM35664 erk000628::pyrimidylpyrrole, 11l

SMILES Cc1cnc(Nc2cccc3OCCOc23)nc1-c1c[nH]c(c1)C(=O)N[C@H](CO)c1cccc(Cl)c1

InChI Key InChIKey=MPCQRPKDRXWSSR-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 35664   

TargetAurora kinase A(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35664(erk000628 | pyrimidylpyrrole, 11l)
Affinity DataKi:  11nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2009
Entry Details Article
PubMed
LigandPNGBDBM35664(erk000628 | pyrimidylpyrrole, 11l)
Affinity DataKi:  15nMAssay Description:Assay 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2012
Entry Details PubMed
LigandPNGBDBM35664(erk000628 | pyrimidylpyrrole, 11l)
Affinity DataKi:  15nM ΔG°:  -10.8kcal/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2009
Entry Details Article
PubMed
LigandPNGBDBM35664(erk000628 | pyrimidylpyrrole, 11l)
Affinity DataKi:  15.1nMAssay Description:Photometric_Method2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2017
Entry Details
D3R

TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35664(erk000628 | pyrimidylpyrrole, 11l)
Affinity DataKi:  45nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2009
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35664(erk000628 | pyrimidylpyrrole, 11l)
Affinity DataKi:  138nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2009
Entry Details Article
PubMed