BDBM357065 (S)-2-(24-(((2-(tert-butoxy)ethoxy)carbonyl)amino)-4-oxo-3-aza -1(1,3),2(1,2)-dinenzenacyclononaphane-9-yl)-5-(3-chloro-2,6-difluorophenyl)pyridine 1-oxide::US10214512, Example 45

SMILES CC(C)(C)OCCOC(=O)Nc1ccc-2c(NC(=O)CCCC[C@@H](c3cccc-2c3)c2ccc(c[n+]2[O-])-c2c(F)ccc(Cl)c2F)c1

InChI Key InChIKey=TUSKELNUILZYRS-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357065   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357065((S)-2-(24-(((2-(tert-butoxy)ethoxy)carbonyl)amino)...)
Affinity DataKi:  0.240nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetKallikrein-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357065((S)-2-(24-(((2-(tert-butoxy)ethoxy)carbonyl)amino)...)
Affinity DataKi:  0.440nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent