BDBM358072 ((2S,4R)-2-(3-(4-Amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl) pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl)-4-hydroxypyrrolidin-1-yl)(cyclopropyl)methanone::US10214537, Example 141
SMILES Nc1ncnn2c(cc(-c3ccnn3C3CCOCC3)c12)-c1cccc(c1)[C@@H]1C[C@@H](O)CN1C(=O)C1CC1
InChI Key InChIKey=HQNVTLVVGHHAOG-QPPBQGQZSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 358072
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Bristol-Myers Squibb
US Patent
Bristol-Myers Squibb
US Patent
Affinity DataIC50: 0.5nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair