BDBM358637 4-(4-amino-5-(1-(2,2,2-trifluoroethyl)- 1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4] triazin-7-yl)-2-((5S,6S)-2,2,5,6- tetramethyl-3-oxomorpholino) benzonitrile::US10214537, Example 714

SMILES C[C@@H]1OC(C)(C)C(=O)N([C@H]1C)c1cc(ccc1C#N)-c1cc(-c2ccnn2CC(F)(F)F)c2c(N)ncnn12

InChI Key InChIKey=MHWZNVQTQXGHCM-GJZGRUSLSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 358637   

LigandPNGBDBM358637(4-(4-amino-5-(1-(2,2,2-trifluoroethyl)- 1H-pyrazol...)
Affinity DataIC50:  0.200nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent