BDBM358665 4-(4-amino-5-chloropyrrolo[2,1-f] [1,2,4]triazin-7-yl)-2-(3,3-dimethyl-4- (3-(3-methyl-1H-pyrazol-1- yl)propanoyl)-2-oxopiperazin-1- yl)benzonnitrile::US10214537, Example 742

SMILES Cc1ccn(CCC(=O)N2CCN(C(=O)C2(C)C)c2cc(ccc2C#N)-c2cc(Cl)c3c(N)ncnn23)n1

InChI Key InChIKey=SSUIICBDLSZQSI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 358665   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM358665(4-(4-amino-5-chloropyrrolo[2,1-f] [1,2,4]triazin-7...)
Affinity DataIC50:  0.700nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent