BDBM358739 (S)-4-acetyl-1-(5-(4-amino-5- chloropyrrolo[2,1-f][1,2,4]triazin-7- yl)-2-(1-hydroxypropyl)phenyl)-3,3- dimethylpiperazin-2-one::US10214537, Example 818

SMILES CC[C@H](O)c1ccc(cc1N1CCN(C(C)=O)C(C)(C)C1=O)-c1cc(Cl)c2c(N)ncnn12

InChI Key InChIKey=FFJRTAZXXLSBIY-IBGZPJMESA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 358739   

LigandPNGBDBM358739((S)-4-acetyl-1-(5-(4-amino-5- chloropyrrolo[2,1-f]...)
Affinity DataIC50:  0.5nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent