BDBM360394 (4-(2H-1,2,3-triazol-2-yl)thiophen-3- yl)((2R,5R)-5-(4-((S)-2-hydroxybutan-2- yl)-5-methyloxazol-2-yl)-2- methylpiperidin-1-yl)methanone::US9828368, Example 46

SMILES CC[C@](C)(O)c1nc(oc1C)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1cscc1-n1nccn1

InChI Key InChIKey=QIFHYQSASFBJSW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 360394   

TargetOrexin receptor type 2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM360394(US9828368, Example 46 | (4-(2H-1,2,3-triazol-2-yl)...)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human OX2R expressed in CHO cells assessed as inhibition of orexin A-induced intracellular Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM360394(US9828368, Example 46 | (4-(2H-1,2,3-triazol-2-yl)...)
Affinity DataIC50: 37nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360394(US9828368, Example 46 | (4-(2H-1,2,3-triazol-2-yl)...)
Affinity DataIC50: 4.70E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM360394(US9828368, Example 46 | (4-(2H-1,2,3-triazol-2-yl)...)
Affinity DataIC50: 9.77E+3nMAssay Description:Antagonist activity at human OX1R expressed in CHO cells assessed as inhibition of orexin A-induced intracellular Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed