BDBM361133 (R)-3'-((4- (aminomethyl)thiazol-2- yl)amino)-N4- (pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3,4- disulfonamide::US10221163, Example 290::US10544130, Example 290

SMILES NCc1csc(Nc2cccc(c2)-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)N[C@@H]2CCNC2)n1

InChI Key InChIKey=VUOAFRFMPXVXJW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 361133   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361133((R)-3'-((4- (aminomethyl)thiazol-2- yl)amino)-N4- ...)
Affinity DataIC50: 0.0870nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361133((R)-3'-((4- (aminomethyl)thiazol-2- yl)amino)-N4- ...)
Affinity DataIC50: 0.0870nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361133((R)-3'-((4- (aminomethyl)thiazol-2- yl)amino)-N4- ...)
Affinity DataIC50: 0.104nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361133((R)-3'-((4- (aminomethyl)thiazol-2- yl)amino)-N4- ...)
Affinity DataIC50: 0.104nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361133((R)-3'-((4- (aminomethyl)thiazol-2- yl)amino)-N4- ...)
Affinity DataIC50: 0.448nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361133((R)-3'-((4- (aminomethyl)thiazol-2- yl)amino)-N4- ...)
Affinity DataIC50: 0.448nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent