BDBM362064 (S)-1-(3-(2-(1-((6-amino-5-cyanopyrimidin-4-yl)(methyl)amino)ethyl)-5-chloro-4-oxoquinazolin-3(4H)-yl)phenyl)-3-ethylurea::US10221197, Compound 57::US10221197, Compound 58

SMILES CCNC(=O)Nc1ccc(Cl)c(c1)-n1c(nc2cccc(Cl)c2c1=O)[C@H](C)Nc1ncnc(N)c1C#N

InChI Key InChIKey=HXKJPCWORONFIS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 362064   

LigandPNGBDBM362064(US10221197, Compound 58 | (S)-1-(3-(2-(1-((6-amino...)
Affinity DataIC50: 2.40E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Gilead Sciences

US Patent
LigandPNGBDBM362064(US10221197, Compound 58 | (S)-1-(3-(2-(1-((6-amino...)
Affinity DataIC50: 5.80E+5nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

LigandPNGBDBM362064(US10221197, Compound 58 | (S)-1-(3-(2-(1-((6-amino...)
Affinity DataIC50: 6.10E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Gilead Sciences

US Patent
LigandPNGBDBM362064(US10221197, Compound 58 | (S)-1-(3-(2-(1-((6-amino...)
Affinity DataIC50: 1.30E+6nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

LigandPNGBDBM362064(US10221197, Compound 58 | (S)-1-(3-(2-(1-((6-amino...)
Affinity DataIC50: 1.00E+7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

LigandPNGBDBM362064(US10221197, Compound 58 | (S)-1-(3-(2-(1-((6-amino...)
Affinity DataIC50: 1.00E+7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent