BDBM362454 (E)-N-(5-fluoro-3-(3-(4-fluoro-2- methoxy-5-methylphenyl)-1H- pyrrolo[2,3-b]pyridin-5-yl)-2- methylphenyl)-2,4,4- trimethylpent-2-enamide::US9834551, Example 173

SMILES COc1cc(F)c(C)cc1-c1c[nH]c2ncc(cc12)-c1cc(F)cc(NC(=O)C(\C)=C\C(C)(C)C)c1C

InChI Key InChIKey=ZBHNQOJCFXPIQG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 362454   

TargetTyrosine-protein kinase ITK/TSK(Human)
Arrien Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 362454BDBM362454(US9834551, Example 173 | (E)-N-(5-fluoro-3-(3-(4-f...)
Affinity DataIC50: 100nMAssay Description:ITK and JAK3 Kinase assay procedures:Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Arrien Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 362454BDBM362454(US9834551, Example 173 | (E)-N-(5-fluoro-3-(3-(4-f...)
Affinity DataIC50: 100nMAssay Description:ITK and JAK3 Kinase assay procedures:Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
US Patent