BDBM367043 4,4,4-trifluoro-1-[4-[2- [4-[4-(tetrahydrofuran- 2-ylmethyl)piperazine- 1-carbonyl]anilino]- [1,2,4]triazolo[1,5- a]pyridin-8-yl]-3,6- dihydro-2H-pyridin-1- yl]butan-1-one::US9873709, Example 2-340

SMILES FC(F)(F)CCC(=O)N1CCC(=CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)N3CCN(CC4CCCO4)CC3)nc12

InChI Key InChIKey=SUGBATOGGVLQQP-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367043   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM367043(4,4,4-trifluoro-1-[4-[2- [4-[4-(tetrahydrofuran- 2...)
Affinity DataKi:  0.310nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM367043(4,4,4-trifluoro-1-[4-[2- [4-[4-(tetrahydrofuran- 2...)
Affinity DataKi:  0.950nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent