BDBM367378 US10226449, cpd 196

SMILES COC1(CCOCC1)c1nc(C)c([nH]1)-c1cc(ccc1C)C(=O)N1CC(C1)c1ccc(cc1)C#N

InChI Key InChIKey=BXUGXPPBWWOJBE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367378   

TargetFatty acid synthase(Human)
3-V Biosciences

US Patent
LigandPNGBDBM367378(US10226449, cpd 196 | US20250017938, Compound 002-...)
Affinity DataIC50: 15nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetFatty acid synthase(Human)
3-V Biosciences

US Patent
LigandPNGBDBM367378(US10226449, cpd 196 | US20250017938, Compound 002-...)
Affinity DataIC50: 15nMAssay Description:Determination of FASN biochemical activity: The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent