BDBM369254 N-[(4-fluorophenyl)methyl]-4-[6-(1- methylsulfonyl-3,6-dihydro-2H-pyridin-4- yl)thieno[3,2-d]pyrimidin-4-yl]piperazine- 1-carboxamide::US10227357, Compound P-0568

SMILES CS(=O)(=O)N1CCC(=CC1)c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1

InChI Key InChIKey=LHMWQPDWCWXZJM-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 369254   

TargetMast/stem cell growth factor receptor Kit [D816V](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM369254(N-[(4-fluorophenyl)methyl]-4-[6-(1- methylsulfonyl...)
Affinity DataKi:  500nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM369254(N-[(4-fluorophenyl)methyl]-4-[6-(1- methylsulfonyl...)
Affinity DataKi:  5.50E+3nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent