BDBM369367 (2R)-N-[(1S)-1-(3-fluorophenyl)ethyl]-2- methyl-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0684

SMILES C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(C)cc12)c1cccc(F)c1

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 369367   

TargetMast/stem cell growth factor receptor Kit [D816V](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM369367((2R)-N-[(1S)-1-(3-fluorophenyl)ethyl]-2- methyl-4-...)
Affinity DataKi:  500nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM369367((2R)-N-[(1S)-1-(3-fluorophenyl)ethyl]-2- methyl-4-...)
Affinity DataKi:  1.05E+5nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent