BDBM370253 6-(2,2-difluoroethyl)-8-[(1R,3R)-3-hydroxycyclohexyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one::BDBM467147::US10233188, Example 140

SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc2cc(CC(F)F)c(=O)n([C@@H]3CCC[C@@H](O)C3)c2n1

InChI Key InChIKey=SBWVCYYEWLZBLS-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 370253   

LigandPNGBDBM370253(BDBM467147 | US10233188, Example 140 | 6-(2,2-difl...)
Affinity DataKi:  0.630nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

LigandPNGBDBM370253(BDBM467147 | US10233188, Example 140 | 6-(2,2-difl...)
Affinity DataKi:  0.630nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/17/2022
Entry Details
US Patent

LigandPNGBDBM370253(BDBM467147 | US10233188, Example 140 | 6-(2,2-difl...)
Affinity DataKi:  0.630nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

LigandPNGBDBM370253(BDBM467147 | US10233188, Example 140 | 6-(2,2-difl...)
Affinity DataKi:  1.97nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

LigandPNGBDBM370253(BDBM467147 | US10233188, Example 140 | 6-(2,2-difl...)
Affinity DataKi:  1.97nMAssay Description:The mobility shift assay electrophoretically separates the fluorescently labeled peptides (substrate and phosphorylated product) following the kinase...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/17/2022
Entry Details
US Patent

LigandPNGBDBM370253(BDBM467147 | US10233188, Example 140 | 6-(2,2-difl...)
Affinity DataKi:  1.97nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent