BDBM371620 (R)-4-(4'-Fluoro-5-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)-N-(pyrimidin-2-yl)chromane-7-sulfonamide::US10239869, Example 44

SMILES Fc1ccc(cc1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F

InChI Key InChIKey=CZZSYEPBDUZHLQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 371620   

LigandPNGBDBM371620(US10239869, Example 44 | (R)-4-(4'-Fluoro-5-(trifl...)
Affinity DataIC50: 16nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandPNGBDBM371620(US10239869, Example 44 | (R)-4-(4'-Fluoro-5-(trifl...)
Affinity DataIC50: 30nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM371620(US10239869, Example 44 | (R)-4-(4'-Fluoro-5-(trifl...)
Affinity DataIC50: 770nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandPNGBDBM371620(US10239869, Example 44 | (R)-4-(4'-Fluoro-5-(trifl...)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of Nav1.5 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed