BDBM371811 4-(2-(1,1-dioxidothiomorpholino)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-4-yl)chromane-7-sulfonamide::US10239869, Example 237

SMILES FC(F)(F)c1ccc([C@H]2CCOc3cc(ccc23)S(=O)(=O)Nc2ccncn2)c(c1)N1CCS(=O)(=O)CC1

InChI Key InChIKey=AITSGHFYOCKIDM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 371811   

LigandPNGBDBM371811(4-(2-(1,1-dioxidothiomorpholino)-4-(trifluoromethy...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM371811(4-(2-(1,1-dioxidothiomorpholino)-4-(trifluoromethy...)
Affinity DataIC50: 19nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandPNGBDBM371811(4-(2-(1,1-dioxidothiomorpholino)-4-(trifluoromethy...)
Affinity DataIC50: 1.00E+4nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent