BDBM371943 US10239870, Example 179::US10239870, Example 182

SMILES Cn1c(SCCCN2CC[C@]3(CC3c3ccc(cc3)C(F)(F)F)C2)nnc1-c1ccc(nc1)C(N)=O

InChI Key InChIKey=PQHIRTDXFUZNBI-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 371943   

TargetD(3) dopamine receptor(Rat)
Indivior

US Patent
LigandPNGBDBM371943(US10239870, Example 182 | US10239870, Example 179)
Affinity DataKi:  0.724nMAssay Description:[125I]-7OH-PIPAT Binding Assay at rat native D3 receptor on membranes from rat ventral striatum. Homogenates from frozen rat brain ventral striatum (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetD(3) dopamine receptor(Rat)
Indivior

US Patent
LigandPNGBDBM371943(US10239870, Example 182 | US10239870, Example 179)
Affinity DataKi:  1.41nMAssay Description:[125I]-7OH-PIPAT Binding Assay at rat native D3 receptor on membranes from rat ventral striatum. Homogenates from frozen rat brain ventral striatum (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM371943(US10239870, Example 182 | US10239870, Example 179)
Affinity DataKi:  794nMAssay Description:CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were re-suspended ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM371943(US10239870, Example 182 | US10239870, Example 179)
Affinity DataKi:  1.48E+3nMAssay Description:CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were re-suspended ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent